National Certified Addiction Counselor, Level I (NCAC I) Practice Exam

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Why was PCP discontinued for human use?

Caused respiratory failure
Induced psychosis
Had no anesthetic properties
Caused addiction

The correct answer is: Induced psychosis

Phencyclidine (PCP), originally developed as an anesthetic, was discontinued for human use primarily because it induced severe psychotic reactions in some users. These psychotic effects could include hallucinations, agitation, and paranoia, which made it unsafe for use in clinical settings. The unpredictable psychological effects significantly outweighed any potential benefits it might have had as an anesthetic. While there were other concerns related to its use, such as respiratory complications and addiction potential, the predominant reason for its discontinuation in humans was the risk of inducing psychosis. This led to a reevaluation of its safety profile, resulting in PCP being classified as a Schedule II controlled substance, primarily for veterinary use, rather than for human patients.